Inta badan waxay ka shaqeeyaan cilmi-baarista Spermidine iyo Spermidine trihydrochloridecan

Inta badan shaqada ku saabsanspermidine iyoSpermidine trihydrochloridekaraa in cilmi-baarista

Spermidine [N-(3-aminopropyl) -1,4-diaminobutane] waa triamine toosan oo buuxa oo inta badan lagu sifeeyo dhexdhexaad ka mid ah isku dhafka shahwada. Waxay leedahay caanaha molecular C1H19N3 iyo molar mass 145.25 g/mol waana molecule yar, biyo-milmi kara, amphifilic ah oo awood u leh inuu dhex galo xuubabka noolaha. Waxay ku dhacdaa noole badan, iyadoon loo eegin kala soocida taxonomic.

Spermidine waxay ku xidhmi kartaa noocyo kala duwan oo unugyo ah, taasoo ka dhigaysa mid aad u faa'iido badan. Waxay taageeraan hababka ay ka mid yihiin korriinka unugyada, xasilloonida DNA, kororka unugyada iyo apoptosis. Waxay u muuqataa in polyamines ay u shaqeeyaan si la mid ah arrimaha koritaanka inta lagu jiro kala qaybinta unugyada. Tani waa sababta spermidine ay muhiim ugu tahay koritaanka iyo shaqada unugyada caafimaadka leh.

1.Anti-bararka spermidine ee kansarka iyo caafimaadka wadnaha

Daraasad 2016, spermidine ayaa la ogaaday inay beddesho saacadda gabowga iyo hagaajinta shaqada wadnaha ee jiirarka da'da ah. Marka la eego heerka xubnaha, qaabka wadnaha iyo shaqada ayaa wanaajiyay jiirarka da'da ah ee la siiyay spermidine. Dheef-shiid kiimikaad ayaa sidoo kale lagu hagaajiyay jiirarkan sababtoo ah dib-u-soo-celinta qaab-dhismeedka mitochondrial iyo shaqada ka dib dheellitirka shahwada.

2. spermidineu dhaqmaya sidii anti-gabowga maaddooyinka

Marka la eego cimri dhererka, daraasado badan oo xayawaan ah ayaa muujiyay in qaadashada shahwadu ay kordhiso cimriga oo ay ka hortagto fibrosis beerka iyo kansarka hepatocellular. Isla sidaas oo kale waxay u muuqataa inay run tahay cuntooyinka hodanka ku ah polyamine. Waxa kale oo jira cadaymo muujinaya in ay kordhiso iska caabinta diiqada, iyo hoos u dhaca da'da ee shahwada shahwada waxay taageertaa horumarinta cudurrada da'da la xidhiidha.

3.Spermidine trihydrochloridekaraa rbaro Hoos u dhaca garaadka

Cilmi baaris lagu daabacay joornaalka Warbixinada Unugyada ee 2021 ayaa tafaasiil ka bixineysa in shahwada cuntada ay wanaajiso garashada iyo shaqada mitochondrial ee duqsiyada iyo jiirarka, oo ay bixiso qaar ka mid ah xogta mustaqbalka ee aadanaha.