NMNH, sheeko cusub iyo horudhac NAD awood leh

Si loo barbardhigo saameynta NMNH iyo NMN, cilmi-baarayaashu waxay dureen PBS iyo 250 mg / kg NMN iyoNMNHgalay jiirarka C57BL/6N, siday u kala horreeyaan, ka dibna la sameeyay muunad dhiig oo xidhiidhsan. Natiijooyinka waxay muujiyeen in NMNH ay si weyn u kordhisay heerarka NAD ee dhiigga, ilaa xad aad uga weyn NMN. NAD waxaa lagu cabbiray unugyadii la ururiyey iyada oo loo marayo habka wareegga enzyme. Natiijooyinku waxay muujiyeen in NMNH ay kordhisay heerarka NAD ee unugyo kala duwan, saameyntuna way ka sarreysey tan NMN. Waxay saameyn muuqata ku yeelatay beerka iyo kelyaha, iyadoo beerka uu kordhay in ka badan 5 jeer, kelyuhuna ay kordheen in ka badan 5 jeer. 2 jeer

NMNH ayaa la kabay inta lagu guda jiro marxaladda reoxygenation, iyo muujinta dhaawaca tuubada kelyaha ee KIM-1 ayaa la ogaaday. Dib-u-kicinta TEC waxay keentay koror xooggan oo ku saabsan muujinta KIM-1, taas oo si aad ah hoos ugu dhacday daaweynta NMNH ka dib, taas oo muujinaysa in maamulkaNMNHwaxay si wax ku ool ah oo aad u yar u yarayn kartaa dhaawaca unugyada epithelial tubular kelyaha inta lagu jiro hypoxia iyo reoxygenation.

Jidka caafimaadkaNMNHtoogtay dhabta ah